Steady State Pharmacokinetics

Ramesh Jayaraman DoseQuartics Consulting

Steady state concentrations and accumulation

Selection of dosing regimen is as important as dose for designing pharmacology and toxicology studies. The objectives of the pharmacology/toxicology studies could be based on answering specific questions such as

1. What is the pharmacological response at steady state concentrations?
2. What is the time required to reach steady state concentrations?
3. What should be the dosing frequency to avoid accumulation?
4. What should the infusion dosing rate be to achieve steady state?

Time to achieve steady state is determined by Volume of distribution and clearance. Steady state concentrations are determined by dosing rate and clearance.