Ramesh Jayaraman, DoseQuantics Consulting The KRAS (Kirsten Rat Sarcoma) gene is a rat oncogene homolog in humans that drives myriad...

The male genital tract (MGT) is a site for infection (HIV), cancer (testicular) and disorders (erectile dysfunction). Since it is...

Amiodarone is an antiarrhythmic drug indicated for treatment and prophylaxis of ventricular fibrillation (VF)* and hemodynamically unstable congestive ventricular tachycardia...

Ramesh Jayaraman, DoseQuantics Consulting In anti-bacterial drug discovery and development, preclinical animal models of infection have played a pivotal role...

In drug discovery, in vitro pharmacology studies are fundamental in assessing a drug candidate’s intrinsic efficacy (Emax,activation or Imax,inhibition) and potency...

As the saying goes health is wealth. As long as people are healthy, physically and mentally, all is well. This...

An in vivo study, be it pharmacokinetics (PK), pharmacodynamics (PD), or pharmacokinetic/pharmacodynamic (PK/PD), should be designed to yield data that...

Physiologically based pharmacokinetics (PBPK) describes the pharmacokinetics (PK) of a drug by integrating its physicochemical and in vitro ADME properties (drug...

Ramesh Jayaraman, DoseQuantics Consulting Pvt Ltd The strength of a PK model is evaluated by its ability to predict the...