Ramesh Jayaraman DoseQuartics Consulting Steady state concentrations and accumulation Selection of dosing regimen is as important as dose for designing...

Ramesh Jayaraman DoseQuartics Consulting The Exposure (AUC) of a therapeutic when administered as infusions and bolus When a dose of...

There is a causal relationship between dose, dosage regimen, exposure of drug and its therapeutic benefit and adverse effects (1). To...

Volume of distribution (V) and Clearance (CL) are fundamental pharmacokinetic (PK) parameters that determine the PK properties of a molecule....

Chemotherapy with targeted drugs in cancer is based on the presence of the abnormally expressed drug target (driver mutations that...