Physiologically Based Pharmacokinetic (PBPK) Modelling: Testing a Model

Ramesh Jayaraman, DoseQuantics Consulting Pvt Ltd

The strength of a PK model is evaluated by its ability to predict the behavior of the drug at a dose or regimen that is different from the dose for which the model was developed. When the model successfully predicts PK across dose levels or regimens its robustness and reliability increase. This is illustrated with a PBPK model developed for the HDAC targeted anti-cancer agent Pracinostat