Intravenous Infusion Dosing: Varying Concentrations at Constant Exposure

Ramesh Jayaraman DoseQuartics Consulting

The Exposure (AUC) of a therapeutic when administered as infusions and bolus

When a dose of a drug is administered as an intravenous bolus and as infusions of different durations, the exposures (AUC) will be the same in the dosing interval, under linear conditions. However, the peak concentrations achieved will decrease with increasing durations of infusions, and steady state will be reached when the infusion period approaches the elimination half-life of the drug.