Clearance (CL) relates the rate of elimination of a molecule with its concentration in vivo. Many small molecules are cleared...

The discharge of antibiotics into the environment such as excretion of intact antibiotic drugs from humans (during treatment of infections)...

There are many drugs that are extensively metabolized by the liver by drug metabolizing enzymes (DME). In many cases a...

Dose fractionation (DF) is an experimental method used to identify the pharmacokinetic/pharmacodynamic (PK/PD) index of an anti-bacterial molecule. Two non-compartmental...

The shape of the pharmacokinetic curve is a function of drug dissolution, rate and extent of absorption across the gastro-intestinal...

In critical care medicine, the goal is to deliver therapeutic drug concentrations rapidly in blood and then maintain therapeutic concentrations...

Ramesh Jayaraman DoseQuartics Consulting Steady state concentrations and accumulation Selection of dosing regimen is as important as dose for designing...

Ramesh Jayaraman DoseQuartics Consulting The Exposure (AUC) of a therapeutic when administered as infusions and bolus When a dose of...