Polymorphisms in Drug Metabolizing Enzymes have Therapeutic Implications
Ramesh Jayaraman, Founder-Director, DoseQuantics Consulting Pvt Ltd, India The cytochrome P450 (CYP450) family of enzymes is responsible for the metabolic clearance of a majority of small molecule drugs. Some of the major CYP450 enzymes are CYP3A, CYP2D6, CYP1A, CYP2C9, CYP2C19, CYP2B6 and CYP2E1. For many drugs a single CYP450 can be contribute to the metabolic…